Virtually contamination-free radioactive ion beams can now be provided at ISAC from a new ion-guide laser ion source (IG-LIS) . This IG-LIS allows for experiments on isotopes that for decades have been overwhelmed by contamination from surface-ionized isobars. TRILIS now routinely provides isotopes from 37 different elements. Laser ionization schemes for an additional 24 elements are ready for off-line testing. TRILIS also supports an in-source laser spectroscopy program that investigates fundamental properties of the rarest isotopes such as atomic energy levels and elemental ionization potentials have been determined for the first time  or improved significantly .