Via nuclear reactions induced by a high-energy primary beam of particles, porous uranium carbide with excess graphite is the international benchmark material for the production of exotic isotopes via the isotope on-line (ISOL) method. This process enables a broad range of science programs with increasing interest in the development of cancer imaging and treatment agents . While the production rate for a specific isotope is determined by the primary beam and the target nucleus, the amount of available isotopes can fall a million times below the production yield, caused by losses inside the target material. De-novo engineered material nanostructures show significantly enhanced performance . Combined with new production methodologies, TRIUMF is aiming to meet the future demand in terms of material availability and isotope yields .